Smooth Muscle Biomechanics
Our current research in smooth muscle biomechanics represents a collaborative effort between the departments of Mechanical Engineering, Biochemistry, Pediatrics and Surgery at VCU. Our work is focused on the characterization and modeling of the complex mechanical behavior of smooth muscle and the identification of the physiological mechanisms responsible for this behavior. More specifically, we are characterizing strain softening and adjustable passive stiffness in bladder tissue and developing a new mechanical model for adjustable passive stiffness in smooth muscle. We have recently expanded the scope of our work to include vascular and airway smooth muscles. The significance of this research lies in its potential to provide insight into the physiological mechanisms that affect smooth muscle stiffness and contractile activity, and their potential role in disorders, such as hypertension, asthma and urinary incontinence.