Dr. David V. Svintradze

Research Associate
E-mail: dsvintradze@vcu.edu
Phone: (804) 827-7001
Fax: (804) 827-7030

Address

401 West Main Street, Room E2234
P.O. Box 843015
Richmond, Virginia 23284-3015

Education

Ph.D. Physics and Mathematics, El. Andronikashvili Institute of Physics, Tbilisi, Georgia, 2006
M.S. Molecular Biophysics, Tbilisi State University, Tbilisi, Georgia, 2005
B.S. Physics and Mathematics, Tbilisi State University, Tbilisi, Georgia, 2003

Scientific Activities

Reviewer, International Journal of Biological Macromolecules
Reviewer, Biomacromolecules
Reviewer, Journal of Theoretical Biology

Honors

NATO Collaborative Linkage Grant, Principal Investigator (2006–2008)
International Travel Award, Awarded from Biophysical Society (USA) 2008
International Travel Award, Awarded from Biophysical Society (USA) 2006
Bursary Award, Awarded from Royal Society of Chemistry (UK) 2006
Scholarship of President of Georgia for Young Scientists (Georgia) 2005
Diploma of Third Degree, Third Degree Premium, Prize for young scientists in Physics, Awarded from G. Soros foundation (Georgia) 2003
Diploma of Third Degree, Premium of Third Degree, Prize for young scientists in Biophysics, Awarded from Tbilisi State University (Georgia) 2002
Diploma of First Degree, Premium of First Degree, Prize for graduate students in physics, Awarded from G. Soros foundation (Georgia) 2002
Diploma of First Degree, Diploma for graduate-undergraduate students, Awarded from Scientific Committee of Physics Faculty, Tbilisi State University (Georgia) 2002

Research Interests

Topology of biological macromolecules
Non-equilibrium systems and statistical physics
Collagen-DNA/siRNA complexes
General theory of hydrophobic-hydrophilic interactions
Self-assembly systems in biochemistry
Non-contacting interactions between biological macromolecules
Non-equilibrium nature of biological macromolecules
DNA/RNA recognition
Gene delivery systems
Collagen-DNA complex as an new biomaterial

Teaching Interests

Molecular Biophysics
Thermodynamics of Biological Systems

Publication

Svintradze, D.V. (2008) “Novel Theoretical Vision of Biomacromolecular Topology and Geometry of Hydrogen Bonds in Water,” submitted to Journal of Chemical Theory and Computation.
Svintradze, D. V. (2008) “Hypothetic Non-equilibrium Systems and Entropy,” in preparation.
Pidaparti, R. M., Shan, Y., Yokota H., and Svintradze, D. V. (2008) “Optimization of Hydrogen-Bonds for Combined DNA/Collagen Complex,” submitted to Journal of Theoretical Biology.
Svintradze, D.V. et al. (2008) “Collagen-DNA complex,” Biomacromolecules, vol. 9, pp. 21–28.
Svintradze, D.V. et al. (2007) “Investigation of collagen-DNA films,” Journal of Physical Biology and Chemistry, vol. 7, pp. 107–116.
Svintradze, D.V., Mrevlishvili, G.M. (2008) “Fiber molecular model of collagen triple helix and DNA double helix complex in aqueous solution,” Asian Journal of Biochemistry, vol. 1, pp. 18–27.
Svintradze, D.V., Mrevlishvili, G.M. (2005) “Fiber molecular model of atelocollagen-small interfering RNA (siRNA) complex,” International Journal of Biological Macromolecules, vol. 37, pp. 283–286.
Svintradze, D.V., Mrevlishvili, G.M. (2005) “DNA as a matrix of collagen fibrils,” International Journal of Biological Macromolecules, vol. 36, pp. 324–326.
Mrevlishvili, G.M., Svintradze, D.V. (2005) “Complex between triple helix of Collagen and double helix of DNA in aqueous solution,” International Journal of Biological Macromolecules, vol. 35, pp. 243–245.
Mrevlishvili, G. M., Svintradze, D. V. (2008) “Supramolecular self-assembly systems in biochemistry: Complex between triple helix of Collagen and double helix of DNA in aqueous solution,” Bulletin of the Georgian Academy of Sciences, vol. 169, pp. 367–379.

Conference Publications

Svintradze, D.V. (2008) “Entropy definition of non-equilibrium biological macromolecules,” Biophysical Journal, Abstracts Issue. Fifty-Second Annual Meeting of the Biophysical Society, and 16th IUPAB International Biophysics Congress, Long Beach CA, USA, 2–6 February.
8th Course: BIOPHYSICS AND THE CHALLENGES OF EMERGING THREATS, Ettore Majorana Foundation and Centre for Scientific Culture, Erice–Sicily, Full Financial Support from NATO ASI Program, “Geometry of hydrogen bonds and collagen-DNA complex”, Italy, 19–30 June 2007.
Svintradze, D.V. (2007) “Prediction of Topology of Biological Macromolecules,” Biophysical Journal, Abstracts Issue, p. 154, 51th Annual Meeting of the Biophysical Society, Baltimore, USA, 4–7 March.
Svintradze, D.V., Mrevlishvili, G.M. (2006) “A mechanism of interaction between collagen triple helix and DNA double helix in aqueous solution,” Biophysical Journal, Abstracts Issue, p. 203, 50th Annual Meeting of the Biophysical Society, Salt Lake City, Utah, USA, 18–22 February.
Svintradze, D.V., Mrevlishvili, G.M. (2005) “Complex between triple helix of collagen and double helix of DNA in aqueous solution,” European Biophysics Journal, vol. 34, p. 729, International Biophysics Congress, Montpellier, France 27 August–1 September.
Mrevlishvili, G.M., Svintradze, D.V. (2005) “DNA as a matrix of collagen fibrils in collagen diseases,” Les Nouvelles Dermatologiques, vol. 24, p. 53, Fourth World Congress of the International Academy of Cosmetic Dermatology. Paris, France 3–5 July.