Virginia Commonwealth University

VCU Chemical and Life Science Engineering

Faculty & staff

Dr. Fong
Dr. Stephen S. Fong
Assistant professor
Phone: (804) 827-7038
Fax: (804) 828-3846
E-mail: ssfong@vcu.edu
Web site: www.engineering.vcu.edu/fong-lab
Address
601 West Main Street, Room 422
P.O. Box 843028
Richmond, Virginia 23284-3028

Education

  • Ph.D., Bioengineering, University of California, San Diego, 2004
  • M.S., Bioengineering, University of California, San Diego, 2001
  • B.S., Chemical Engineering, Worcester Polytechnic Institute, 1998

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Research interests

  • Systems biology
  • Evolutionary biology
  • Metabolic engineering
  • Molecular engineering
  • Molecular evolution
  • Computational modeling

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Recent publications

  • Fong, S.S. ?œEvolutionary engineering of industrially important microbial phenotypes??in Metabolic Pathway Engineering Handbook. CRC press. In press.
  • Fong, S.S. ?œGenome-Scale Assessment of Phenotypic Changes during Adaptive Evolution??in Introduction to Systems Biology. Humana Press. In press.
  • Reed, J.L., Patel, T.R., Chen, K.H., Joyce, A.R., Applebee, M.K., Herring, C.D., Knight, E.M., Fong, S.S., Palsson, B.O. Systems Approach to Genome Annotation. Proceedings of the National Academy of Sciences USA. Nov 14;103(46):17480-17484. (2006)
  • Hua, Q., Joyce, A.R., Fong, S.S., Palsson, Metabolic analysis of adaptive evolution for in silico designed lactate-producing strains. Biotechnology & Bioengineering. Dec 5;95(5):992-1002. (2006)
  • Herrgard, M.J., Fong, S.S., Palsson, B.Ø. Systematic identification of genome-scale metabolic models using experimentally measured flux profiles. PLoS Computational Biology. July 7;2(7):e72 . (2006)
  • Fong, S.S.*, Perrenoud, A.*, Palsson, B.O., Sauer, U. Latent pathway activation and increased pathway capacity enable Escherichia coli adaptation to loss of key metabolic enzymes. Journal of Biological Chemistry. 281(12):8024-8033. (2006)
  • Fong, S.S., Joyce, A.R., Palsson, B.O. Parallel adaptive evolution cultures of Escherichia coli lead to convergent phenotypes with different expression states. Genome Research. 15:1365-1372. (2005)
  • Fong, S.S., Joyce, A.R., Palsson, B.O. The econometrics of evolution. Nature Chemical Biology. 1(4):191-192. (2005)
  • Fong, S.S., Burgard, A.P., Herring, C.H., Knight, E.M., Blattner, F.R., Maranas, C.D., Palsson, B.O. In silico design and adaptive evolution of Escherichia coli for production of lactic acid. Biotechnology & Bioengineering. 91(5):643-648. (2005)
  • Fong, S.S., Palsson, B.O. Metabolic gene deletion strains of Escherichia coli evolve to computationally predicted growth phenotypes. Nature Genetics. 36(10):1056-8. (2004)
  • Fong, S.S., Marciniak, J.Y., Palsson, B.O. Description and interpretation of adaptive evolution of Escherichia coli K-12 MG1655 by using a genome-scale in silico metabolic model. Journal of Bacteriology. 185(21):6400-8. (2003)
  • Reed, J.L., Fong, S.S., Palsson, B.O. ?œPhenomics??in Microbial Diversity and Bioprospecting ASMPress 2003. (2003)
  • Francis, K., Palsson B., Donahue, J., Fong, S., Carrier, E. Murine Sca-1(+)/Lin(-) cells and human KG1a cells exhibit multiple pseudopod morphologies during migration. Experimental Hematology. 30(5):460-3. (2002)
  • Lee, G.M., Fong, S.S., Oh, D.J., Francis, K., Palsson, B.O. Characterization and efficacy of PKH26 as a probe to study the replication history of the human hematopoietic KG1a progenitor cell line. In Vitro Cell. & Developmental Biology Animal. 38(2):90-6. (2002)
  • Lee, G.M., Fong, S., Francis, K., Oh, D.J., Palsson, B.O. In situ labeling of adherent cells with PKH26. In Vitro Cell. & Developmental Biology Animal. 36(1):4-6. (2000)
  • Pazzano D., Mercier K.A., Moran J.M., Fong S.S., DiBiasio D.D., Rulfs J.X., Kohles S.S., Bonassar L.J. Comparison of chondrogensis in static and perfused bioreactor culture. Biotechnology Progress. 16(5):893-6. (2000)

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