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Advanced Courses in Supercritical Fluid Technology

• “Processing With Supercritical Fluids,” a one-day course presented at AIChE Meetings (1989 - 90; 1983 - 85), co-lecturer: V.J. Krukonis.
• “Thermodynamics of Supercritical Fluid Systems,” a two-day course, Los Alamos, N.M., March 1997; co-lecturer: M.E. Paulaitis.
• “Supercritical Fluid Extraction: Principles and Practice,” a two and one-half day course, Boston, Mass. (1990 - 2000), Univ. of Notre Dame (1984 - 85), Battelle Northwest Laboratories in Pasco, Wash. (1985), Johns Hopkins University (1986 - 89) and at the Jysk Institute, Denmark (1989); co-lecturer: V.J. Krukonis.

Books Authored

• McHugh, M.A. and V.J. Krukonis, “Supercritical Fluid Extraction: Principles and Practice,” Butterworth, Stoneham, Mass., First Edition, 4/86; 2nd Edition, 512 pages, January 1994.

Books Edited

• Penninger, J.M.L., Radosz, M., McHugh, M.A., and V.J. Krukonis, eds., “Symposium Proceedings on Supercritical Fluid Technology,” Elsevier Science Publishers, October 1985.
• McHugh, M.A., ed., “Proceedings of the Second International Symposium on Supercritical Fluids,” May 1991.

Editorial Advisory Board

• “Chemical & Engineering Technology,” 1998 - Present
• “Chemical and Engineering Data,” 1998 - 2001
• “Journal of Supercritical Fluids,” 1990 - Present

Education

• B.S., Chemical Engineering; Carnegie-Mellon University, 1975
• Ph.D., Chemical Engineering; University of Delaware, 1981

Honors and Awards

• Battelle Memorial Institute Research Award, October 1984
• JHU Oraculum Award for Excellence in Undergraduate Teaching, F92, F93, S94, S95
• Visiting Professor, Institut für Physikalische Chemie, Universität Göttingen, May - Dec. 1994
• Kipping Visiting Professor, Chemistry Department, University of Nottingham, March 1996

Professional Activities

• APS: High Polymer Physics
• ACS: Polymer Mat. Science and Eng. Division; Polymer Chem. Division

Professional Employment Experience

• 1975 - 1976
  Process Engineer, FMC Corp., Chemical R&D, Princeton, N.J.
• 1981 - 1985
  Asst. Professor, Department of Chemical Engineering, University of Notre Dame
• 1985 - 1987
  Asst. Professor, Department of Chemical Engineering, Johns Hopkins University
• 1987 - 1991
  Assoc. Professor, Department of Chemical Engineering, Johns Hopkins University
• 1991 - 1999
  Professor, Department of Chemical Engineering, Johns Hopkins University
• 1999 - Present
  Professor, Chemical Engineering, Virginia Commonwealth University

Refereed Articles -- 1994

• Lee, S.-H., LoStracco, M.A., Hasch, B.M., and M.A. McHugh, “Solubility of poly(ethylene-co-acrylic acid) in low molecular weight hydrocarbons:  Effect of copolymer concentration, solvent quality, and copolymer molecular weight,” Journal of Physical Chemistry, 98, 4055-4060 (1994).
• McHugh, M.A., “Copolymer solution behavior in supercritical fluids,” in “Supercritical fluids - Fundamentals for application,” NATO ASI Series E, Kluwer Academic Publishers, 273, 599-617 (1994).
• Hasch, B.M., Maurer, E.J., Ansanelli, L.F., and M.A. McHugh, “(Methanol+Ethene):  Phase behavior and modeling with the SAFT equation of state,” Journal of Chemical Thermodynamics, 26, 625-640 (1994).
• LoStracco, M.A., Lee, S.-H., and M.A. McHugh, “Comparison of the effect of density and hydrogen bonding on the cloud-point behavior of poly(ethylene-co-methyl acrylate)-propane-cosolvent mixtures,” Polymer,  35, 3272-3277 (1994).
• McHugh, M.A., V.J. Krukonis, and J.A. Pratt, “Supercritical fractionation of polymers and copolymers,” Trends in Polymer Science, 2, 301-307 (1994).
• Lee, S.-H., LoStracco, M.A., and M.A. McHugh, “High-pressure, molecular weight dependent behavior of (co)polymer mixtures: experiments and modeling,” Macromolecules, 27, 4652-4658 (1994).

Refereed Articles -- 1995

• Hasch, B.M. and M.A. McHugh, “Calculating poly(ethylene-co-acrylic acid)-solvent phase behavior with the SAFT equation of state,” Journal of Polymer Science: Polymer Physics, 33, 715-723 (1995).
• Tuminello, W.H., G.T. Dee, and M.A. McHugh, “Dissolving perfluoropolymers in supercritical carbon dioxide,” Macromolecules, 28, 1506-1510 (1995).

Refereed Articles -- 1996

• Hasch, B.M., Lee, S.-H., and M.A. McHugh, “Strengths and limitations of SAFT for calculating polar copolymer-solvent phase behavior,” Journal of Applied Polymer Science, 59, 1107-1116 (1996).
• Lee, S.-H., LoStracco, M. A., and M.A. McHugh, “Cosolvent effect on the phase behavior of poly(ethylene-co-acrylic acid)-butane mixtures,” Macromolecules, 29, 1349-1358 (1996).
• Byun, H.-S., Hasch, B.M., McHugh, M.A., Mähling, F.-O., Busch, M., and M. Buback, “Poly(ethylene-co-butyl acrylate).  Phase behavior in ethylene compared to the poly(ethylene-co-methyl acrylate)-ethylene system and aspects of copolymerization kinetics at high pressures,” Macromolecules, 29, 1625-1632 (1996).
• Byun, H.-S., Hasch, B.M. and M.A. McHugh, “Phase behavior and modeling of the systems CO2-acetonitrile and CO2-acrylic acid,” Fluid Phase Equilibria, 115, 179-192 (1996).
• Pratt, J.A. and M.A. McHugh, “Supercritical fluid fractionation of poly(ethylene-co-acrylic acid),” Journal of Supercritical Fluids, 9, 61-66 (1996).
• Lee, S.-H., Hasch, B.M. and M.A. McHugh, “Calculating copolymer solution behavior with Statistical Associating Fluid Theory,” Fluid Phase Equilibria, 117, 61-68 (1996).
• Rindfleisch, F., DiNoia, T.P., and M.A. McHugh, “Solubility of polymers and copolymers in supercritical CO2,” Journal of Physical Chemistry, 100, 15581-15587 (1996).
• Mertdogan, C.A., Byun, H.-S., McHugh, M.A., W.H. Tuminello, “Solubility of poly(tetrafluoroethylene-co-19 mol% hexafluoropropylene) in supercritical CO2 and halogenated supercritical solvents,” Macromolecules, 29, 6548-6555 (1996).

Refereed Articles -- 1997

• Lee, S.-H. and M.A. McHugh, “Phase behavior studies with poly(ethylene-co-methacrylic acid) at high pressures,” Polymer, 38, 1317-1322 (1997).
• Kirby, C.F. and M.A. McHugh, “A simple method for measuring refractive index of supercritical fluids,” Review of Scientific Instruments, 68, 3150-3153 (1997).
• Buback, M., Elstner, U., Rindfleisch, F., and M.A. McHugh, “Modification of ethylene-based copolymers in near-critical water,” Macromolecular Chemistry and Physics, 198, 1189-1196 (1997).
• Kordikowski, A., DiNoia, T.D., Aguiar-Ricardo, A., Robertson, D.G., McHugh, M.A., and M. Poliakoff, “Acoustic determination of the critical surfaces in the ternary systems CO2 + CH2F2 + CF3CH2F and CO + C2H4 + CH3CHCH2 and in their Binary Subsystems,” Journal of Physical Chemistry B, 101, 5853-5862 (1997).
• Mertdogan, C.A., DiNoia, T.P., McHugh, M.A., “The impact of backbone architecture on the solubility of fluorocopolymers in supercritical CO2 and halogenated supercritical solvents: Comparison of poly(vinylidene fluoride-co-22 mol% hexafluoropropylene) to poly(tetrafluoroethylene-co-19 mol% hexafluoropropylene),” Macromolecules, 30, 7511-7515 (1997).

Refereed Articles -- 1998

• McHugh, M.A., Mertdogan, C.A., DiNoia, T.P., Anolick, C., Tuminello, W.H., and R. Wheland, “Impact of melting temperature on poly(tetrafluoroethylene-co-hexafluoropropylene) solubility in supercritical fluid solvents,” Macromolecules, 31, 2252-2254 (1998).
• DiNoia, T.P., M.A. McHugh, Cocchiaro, J.E., and J.B. Morris, “Solubility and phase behavior of PEP binder polymers in supercritical carbon dioxide,” Waste Management, 17, 151-158 (1998).
• Mertdogan, C.A., McHugh, M.A., Barth, H.G., Walls, D.J., and W.H. Tuminello, “Supercritical fractionation of a perfluorinated copolymer,” International Journal of Polymer Analysis and Characterization, 4, 231-246 (1998).
• Lee, S-H and M.A. McHugh, “Phase behavior of copolymer-copolymer-solvent mixtures at high pressures,” Polymer, 39, 5447-5451 (1998).
• McHugh, M.A., Rindfleisch, F., Kuntz, P.T., Schmaltz, C., and M. Buback, “Cosolvent effect of alkyl acrylates on the phase behavior of poly(alkyl acrylates)-supercritical CO2 mixtures,” Polymer, 39, 6049-6052 (1998).

Refereed Articles -- 1999

• Kirby, C.F. and M.A. McHugh, “Phase behavior of polymers in supercritical fluid solvents,” Chemical Reviews, 99, 565-602 (1999).
• Lora, M., Lim, J.-S, and M.A. McHugh, “Comparison of the solubility of PVF and PVDF in supercritical CH2F2 and CO2 and in CO2 with acetone, dimethyl ether, and ethanol,” Journal of Physical Chemistry B, 103, 2818-2822 (1999).
• Lora, M., Rindfleisch, F., and M.A. McHugh, “Influence of the alkyl tail on the solubility of poly(alkyl acrylates) in ethylene and CO2 at high pressures:  Experiment and Modeling,” Journal of Applied Polymer Science, 73, 1979-1991 (1999).
• Lora, M. and M.A. McHugh, “Phase behavior and modeling of the poly(methyl methacrylate)-CO2-methyl methacrylate system,” Fluid Phase Equilibria, 157, 285-297 (1999).
• Mertdogan, C.A., McHugh, M.A., and W.H. Tuminello, “Cosolvency effect of SF6 on the solubility of poly(tetrafluoroethylene-co-19 mol% hexafluoropropylene) in supercritical CO2 and CHF3,” Journal of Applied Polymer Science, 74, 2039-2045 (1999).
• Beyer, C., Oellrich, L.R., and M.A. McHugh, “Effect of copolymer composition and solvent polarity on the phase behavior of mixtures of poly(ethylene-co-vinyl acetate) with cyclopentane and cyclopentene,” Chemie Ingenieur Technik, 71, 1306-1310 (1999) also in Chemical Engineering Technology, 23, 592 (2000).

Refereed Articles -- 2000

• Byun, H.-S., DiNoia, T.P., and M.A. McHugh, “High pressure densities of ethane, pentane, pentane-d12, 25.5 wt% ethane in pentane-d12, 2.4 wt% deuterated poly(ethylene-co-butene) (PEB) in ethane, 5.3 wt% hydrogenated PEB in pentane, 5.1 wt% hydrogenated PEB in pentane-d12, and 4.9 wt% hydrogenated PEB in pentane-d12 + 23.1 wt% ethane,” Journal of Chemical and Engineering Data, 45, 810-814 (2000).
• DiNoia, T.P., Conway, S.E., Lim, J.-S., and M.A. McHugh, “Solubility of vinylidene fluoride polymers in supercritical CO2 and halogenated solvents,” Journal of Polymer Science: Part B: Polymer Physics, 38, 2832-2840 (2000).
• DiNoia, T.P., Kirby, C.F., van Zanten, J.H., and M.A. McHugh, “SANS study of polymer-supercritical fluid solutions: Transitions from liquid to supercritical fluid solvent quality,” Macromolecules, 33, 6321-6329 (2000).
• Byun, H.-S., Kim, K., and M.A. McHugh, “Phase behavior and modeling of supercritical carbon dioxide-organic acid mixtures,” Industrial and Engineering Chemistry Research, 39, 4580-4587 (2000).
• Byun, H.-S. and M.A. McHugh, “Impact of “free” monomer concentration on the phase behavior of supercritical carbon dioxide-polymer mixtures,” Industrial and Engineering Chemistry Research, 39, 4658-4662 (2000).

Refereed Articles -- 2001

• Conway, S.E., Byun, H.-S., McHugh, M.A., Wang, J.D., and F.S. Mandel, “Poly(lactide-co-glycolide) solution behavior in supercritical CO2, CHF3, and CHClF2,” Journal of Applied Polymer Science, 80, 1155-1161 (2001).
• Conway, S.E., Lim, J.S., McHugh, M.A., Wang, J.D., and F.S. Mandel, “Phase behavior of a semi-crystalline polyester resin in supercritical fluid (SCF) solvents and solvent mixtures:  Implications for SCF processing,” Journal of Applied Polymer Science, 81, 2642-2648 (2001).

Refereed Articles -- 2002

• McHugh, M.A., Wang, J.D., and F.S. Mandel, “Supercritical fluid processing of polymeric materials,” in Supercritical Fluid Technology in Materials Science: Synthesis, Properties, and Applications,  Y.-P. Sun, Ed., Marcel Dekker, Inc., 227-254 (2002).
• McHugh, M.A., Park, I.-H., Ren, Y., Reisinger, J.J., Lodge, T.P., and M.A. Hillmyer, “Solubility of CF2-modified polybutadiene and polyisoprene in supercritical carbon dioxide,” Macromolecules,  35, 4653-4657 (2002).
• Garach-Domech, A., Rock, D., Sandhu, G., Russell, J., McHugh, M.A., and B.K. MacIver, “Phase behavior of diethyl methylphosphonate and 2-chloroethyl methyl sulfide in supercritical carbon dioxide,” Journal of Chemical and Engineering Data, 47, 984-986 (2002).
• Lee, S-H and M.A. McHugh, “The effect of hydrogen bonding on the phase behavior of poly(ethylene-co-acrylic acid)-ethylene-cosolvent mixtures at high pressures,” Korean Journal of Chemical Engineering, 19, 114-119 (2002).
• Lee, S.-H. and M.A. McHugh,“Phase behavior of 4-methoxyphenyl acetic acid in carbon dioxide,”  Journal of Chemical and Engineering Data, 47, 792-795 (2002).
• McHugh, M.A., Garach-Domech, A., Park, I.H., Barbu, E., Graham, P., and J. Tsibouklis, “Impact of fluorination and side-chain length on poly(methylpropenoxyalkylsiloxane) and poly(alkyl methacrylate) solubility in supercritical carbon dioxide,” Macromolecules, 35, 6479-6482 (2002).

Refereed Articles -- 2003

• Shen, Z., McHugh, M.A., Xu, J., MacPhearson, H., Kilic, S., Mesiano, A., Bane, S., Karnikas, C., Beckman, E., and R. Enick, “CO2-solubility of oligomers and polymers that contain the carbonyl group,” Polymer, 44, 1491-1498 (2003).
• Wright, M.E., Lott, K.M., Shen, Z., and M.A. McHugh, “Synthesis of fluorinated and hydrocarbon ester functionalized poly(p-phenylenes) and their solubility in supercritical fluids,” Macromolecules, 36, 2242-2247 (2003).
• DiNoia, T.P., van Zanten,  J.H., Kline, S.R., Garach-Domech, A., McHugh, M.A., Wright,  P.J., and L.J. Fetters, “Impact of supercritical fluid solvent quality on polymer conformation in semidilute solutions: SANS data for poly(ethylene-co-1-butene) in dimethyl ether to kilobar pressures,” Macromolecules, 36, 7372-7378 (2003).
• Li, D., Shen, Z., McHugh, M.A., Tsibouklis, J., and E. Barbu, “Solubility of poly(perfluoromonoitaconates) and poly(perfluorodiitaconates) in supercritical CO2,” Industrial and Engineering Chemistry Research, 42, 6499-6504 (2003).
• Lesemann, M., Nathan, H., DiNoia, T.P., Kirby,  C.F., McHugh, M.A., van Zanten,  J.H., and M.E. Paulaitis, “Self-assembly at high pressures: SANS study of the effect of pressure on microstructure of C8E5 micelles in water,” Industrial and Engineering Chemistry Research, 42, 6425-6430 (2003).

Refereed Articles -- 2004

• McHugh, M.A. and D. Li, “Limited polysulfone solubility in supercritical fluid (SCF) solvent + cosolvent mixtures,” Journal of Supercritical Fluids, 28, 79-83 (2004).
• McHugh, M.A. and D. Li, “Solubility behavior of ethyl cellulose in supercritical fluid solvents,” Journal of Supercritical Fluids, 28, 225-231 (2004).
• Shen, Z., McHugh, M.A., Lott, K.M., and M.E. Wright, “Solubility of semi-fluorinated and nonfluorinated alkyl dichlorobenzoates in supercritical CO2,” Fluid Phase Equilibria, 216, 1-12 (2004).
• McHugh, M.A., “Solubility of polymers in supercritical CO2,” in Green Chemistry Using Liquid and Supercritical Carbon Dioxide, J.M. DeSimone and W. Tumas, Eds., Oxford University Press, pg 125-133, 8 January 2004.
• Shen, Z., Sandhu, G., Li, D., Bara, C.E., Waldrup, S.B., Siddiqui, S., Dillon, C.R., MacIver, B.K., and M.A. McHugh, “Solubility of chemical warfare agent simulants in supercritical carbon dioxide: Experiments and Modeling,” Journal of Supercritical Fluids, 30, 273-280 (2004).
• Baradie, B., Shoichet, M.S., Shen, Z., McHugh, M.A., Hong, L., Wang, Y., Johnson, J.K., Beckman, E.J., and R.M. Enick, “Synthesis and solubility of linear poly(tetrafluoroethylene-co-vinyl acetate) in dense CO2: Experimental and molecular modeling results,” Macromolecules, 37, 7799-7807 (2004).
• Kermis, T.W., Li, D., Guney-Altay, O., Park, I.-H., van Zanten, J.H., and M.A. McHugh, “High-pressure dynamic light scattering of poly(ethylene-co-1-butene) in ethane, propane, butane, and pentane at 130°C and kilobar pressures,” Macromolecules, 37, 9123-9131 (2004).

Refereed Articles -- 2005

• Li, D., McHugh, M.A., and J.H. van Zanten, “Density induced phase separation in poly(ethylene-co-1-butene)-dimethyl ether solutions,” Macromolecules, 38, 2837-2843 (2005).
• Shen, Z., McHugh, M.A., Smith, D.W., Abayashinghe, N.K., and J. Jin, “Impact of hexafluoroisopropylidene on the solubility of aromatic-based polymers in supercritical fluids,” Journal of Applied Polymer Science, 97, 1736-1743 (2005).
• DiNoia, T.P, Park, I.-H, McHugh, M.A., and J.H. van Zanten, “Observation of polymer chain contraction near the overlap concentration,” Macromolecules, 38, 9393-9395 (2005).
• Shen, Z., Lott, K.M., Wright, M.E., and M.A. McHugh, “Impact of configuration and fluorination on the solubility of octyl ester benzoate dimers in CO2,” Fluid Phase Equilibria, 238, 210-219 (2005).

Refereed Articles -- 2006

• Kostko, A.F., McHugh, M.A., and J.H. van Zanten, “Coil-coil interactions for poly(dimethyl siloxane) in compressible supercritical CO2,” Macromolecules, 39, 1657-1659 (2006).
• Wright, M.E., Gorish, C.E., Shen, Z., and M.A. McHugh, “2,5-Dichloro-1-(ROSO2)benzene [R = C6H5, C6F5, and CH2(CF2)4H]: Synthesis, molecular structure, and solubility in supercritical CO2,” Journal of Fluorine Chemistry, in press (2006).
• Liu, J., Kim, Y.C., and M.A. McHugh, “Phase behavior of the vanillin-CO2 system at high pressures,” Journal of Supercritical Fluids, in press (2006).

Research Interests

• Supercritical fluid solvent technology
• Scattering phenomena in polymer solutions at high pressures
• Polymer solution behavior at high pressures

Scientific Committee Member

• Third International Symposium on Supercritical Fluids, Strasbourg, France, October 1994
• First International Symposium on Science, Engineering, Tech. of Intensive Processing, Nottingham, U.K., September 1995
• Fourth International Symposium on Supercritical Fluids, Sendai, Japan, May 1997
• Fifth International Symposium on Supercritical Fluids, Atlanta, Ga., April 2000
• Sixth International World Congress of Chemical Engineering, High Pressure Processes, Australia, September 2001
• Fourth International Symposium on High Pressure Process Tech. & Chemical Engineering, Venice, Italy, September 2002