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Current Research Topics

• Non-catalytic asymmetric reductions in bulk active pharmaceutical  process development
• Process development of heterocyclic building blocks for pharmaceutical applications

Education

• Ph.D., Organic Chemistry, Virginia Commonwealth University
• M.S., Biochemistry, Georgia Institute of Technology
• B.S., Chemistry, University of Richmond

Patents

• U.S. Patent 4,277,620:  Recovery of Pentaerythritol from Process Waste Streams: B.F. Gupton, and H.E. Ulmer
• U.S. Patent 4,503,262:  Process for Production of 2,6-Diisopropylnapthalenes: B.F. Gupton and E.D. Little
• U.S. Patent 4,612,389:  Treatment of Waste Streams from Penterythritol Manufcture: B.F. Gupton, and H.E. Ulmer
• U.S. Patent 4,871,859:  Process for Preparing Pyridine Carboxylic Acids:, B.F. Gupton, W.H. Mueller and J.H. Rea
  
• U.S. Patent 4,902,819: Preparation of Sodium Diethyl Oxalacetates: B.F. Gupton and J.H. Rea
• U.S. Patent 5,047,542: Process for Preparing Pyridine Carboxylic Acid Esters: B.F. Gupton, W.H. Mueller and J.S. Saukaitis
• U.S. Patent 5,208,342: Preparation of Imidazolanones for Herbicide Applications: B.F. Gupton, and J.S. Saukaitis
• U.S. Patent 5,322,948:  Preparation of N-Hydroxyaspartic Acid Derivatives: V. Elango, J.R. Fritch, D.R. Larkin, B.F. Gupton and W.H. Mueller
  
• U.S. Patent 5,405,987: N-Hydroxyaspartic Acid Derivatives Preparation: V. Elango, J.R. Fritch, D.R. Larkin, M.P. Bodman, B.F. Gupton, W.H. Mueller and J.S. Saukaitis
• U.S. Patent 5,430,152: Preparation of Quinolone Carboxylic Acids: B.F. Gupton and J.C. Saukaitis
• U.S. Patent 6,399,781:  Process for Making 3-Amino-2-chloro-4-methylpyridine: B.F. Gupton
• U.S. Patent 6,680,383:  Process for Making Nevirapine: B.F. Gupton, R. F. Boswell and Y. S. Lo
• U.S.  Patent  7,282,583:  Process for making 5,11-Dihydro-11-ethyl-5-methyl-8{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-d- i pyrido[3,2-b:2',3'-e][1,4]diazepin-6-one: Saeed Ahmad, R.F. Boswell, Jr, J.D.Brown, C.M. Davis, K.O. Donsbach, B.F. Gupton, C.P. Johnson, III, A. Khodabocus, V.R. Kulkarni, Y.S.Lo

Professional Employment Experience

• 1994-2007: Boehringer Ingelheim Chemicals, Inc.- Executive Director, Process Development
• 1987-1993: Hoechst-Celanese Corp.- Project Manager, Commercial Development
• 1976-1986: Celanese Corp.- Senior Project Leader, Research and Development

Publications

• Reaction of Serine Proteases with Aza-Amino Acids:  J.C. Powers and B.F. Gupton: Methods Enzymol., 1977, pp. 208-216.
• Synthetic Inhibitors of Granulocyte Elastase and Cathepsin G:  New Inhibitors and Active Site Titrants:  J.C. Powers and B.F. Gupton: Biochem. Biophys. Acta, 1977,  pp. 156-166.
• Synthetic Elastase Inhibitors and Their Role in The Treatment of Disease:  J.C. Powers and B.F. Gupton: Pept. Synth. Struct. Funct. Proc. Am. Pept. Symp. : 1981, pp. 391-399.
• ecificity Elastase and Cathepsin G.  Inhibition of Cathepsin G:  J.C. Powers and B.F. Gupton: Neut. Prot. Hum. Poly. Leuk., pp. 221-233.
  
• Reaction of Azapeptides with Human Leukocyte Elastase.  New Inhibitors and Active Site Titrants:  J.C. Powers and B.F. Gupton: J. Biol. Chem., 1984, pp. 4288-4294.
• Reaction of Azapeptides with Chymotrypsin-like Enzymes.  New Inhibitors and Active Site Titrants:  J.C. Powers and B.F. Gupton: J. Biol. Chem., 1984, pp. 4279-4284.
• Large Scale Synthesis: B. Frank Gupton and Karl Groezinger.,2003: Burger's Medicinal Chemistry and Drug Discovery, 6th Edition, Vol. 2, Ch. 12 pp.407-430.
• Pharmaceuticals, Large Scale Synthesis, B. Frank Gupton and Karl Grozinger: Kirk-Othmer Encyclopedia of Chemical Technology, 5th Edition (2005), 18 722-746

Research Interests

• Development of commercially viable synthetic tools for the asymmetric reduction of carbonyl compounds
• Rational process design of functionalized imidazoles as building blocks for pharmaceutical applications
• Process development of multi-functional pyridines from acyclic precursors